The Power of Human Milk Oligosaccharides

he Power of Human Milk Oligosaccharides in Infant Nutrition

Sub Heading

Human milk oligosaccharides are beneficial prebiotics that can nourish your baby's immune system

Main Image

Alt text

MAY. 03, 2018  4 MIN. READ

With a perfect blend of proteins, fats, carbohydrates, vitamins, minerals, carotenoids and other components that support a baby's immune system, breast milk is the gold standard for infant nutrition. And within this nutritional powerhouse, there's an unsung hero—human milk oligosaccharides (HMOs). Based on nearly two decades of research, experts believe that it could be one of the factors behind breast milk's immune system-supporting properties.

Until now, human milk oligosaccharides have only been found in breast milk, but thanks to Abbott's cutting-edge research, even moms who choose to use formula can provide their babies with them too. 

What are HMOs?

Human milk oligosaccharides (pronounced ol·i·go·sac·cha·rides) are unique, non-digestible, complex carbohydrates with a prebiotic role; in other words they feed the healthy bacteria in our gut. They are the third most abundant component in breast milk (after fat and carbohydrate) and make up to 10 percent of breast milk. There's even more HMO than protein.

"HMOs feed the beneficial bacteria in the gut where 70 percent of a baby's immune system is found," according to Rachael Buck, Ph.D., an Abbott research scientist and expert in immune health. "But what's very special about HMOs is that they are also absorbed into the bloodstream. This is how they support the immune system beyond the gut," she explains.

There are 150 different types of HMOs and the most abundant one in most mothers' milk is 2'-Fucosyllactose or 2'-FL. As well as its prebiotic role, 2'-FL HMO is beneficial for babies' gut and immune system development.

Breakthrough research

After researching HMOs for more than a decade, in 2010, Abbott scientists made a breakthrough and decided to focus their attention on the most abundant HMO, 2'-FL. Since then, Abbott has published more than 20 pre-clinical and clinical studies on 2'-FL HMO.

In 2016, Abbott researchers compared the immune response of exclusively breastfed babies to that of babies who were exclusively fed formula with and without a structurally identical version of the 2'-FL HMO found in human milk.

After six weeks, researchers discovered that five immune markers were nearly identical between babies who were breastfed and those who were fed Similac with 2'-FL HMO.

The clinical study, published in the Journal of Nutrition, showed that infants fed Similac infant formula supplemented with 2'-FL HMO had the prebiotic in their blood and urine similar to breast fed infants and the same rate of growth as breastfed infants.

"These are ground-breaking results because they show that babies fed the infant formula have an immune response more like breastfed infants," Buck explains. "2'FL HMO helps support a baby's immune system because it helps close multiple gaps in immune function between formula-fed and breastfed babies."

Abbott was the first company in the world to launch an infant formula with 2'-FL HMO. Adding HMO* to the formula brings it closer to breast milk than ever before.

A Healthy Gut

Not only do HMOs support the entire body's immune system by starting in the gut, they may also directly affect gut health. In fact, a study by Abbott shows that the HMOs support baby's developing digestive system.

Nothing can replace breast milk, but for moms who cannot or choose not to breastfeed, or those who need to supplement, an infant formula with 2'-FL HMO is one step closer to closing the gap.

"We want to give parents choices and ensure that even formula babies have the strongest possible start in life," Buck says.

* not from human milk

Formula Preparation: What You Need to Know

Main Image


While breast milk is the gold standard, some women prefer not to breastfeed or cannot rely solely on breast milk alone. For those who use formula, it is important to know the basics of formula preparation to keep your baby healthy. It’s simple, but important to carefully follow the label. Your baby's health depends on it. 

Our Efforts to Address Infant Formula Supply

Main Image



Millions of parents rely on our formula to feed their babies. And we know that our recent recall caused additional stress and anxiety in an already challenging situation of a global supply shortage. We are working hard to help moms, dads and caregivers get the high-quality nutrition they need for their babies.


HMOs are unique prebiotics found in breast milk. They are used by the bodyto support digestive health and the immune system. HMOs are unique prebiotics found in breast milk. They are used by the bodyto support digestive health and the immune system.

Learn about HMOs, unique prebiotics in breast milk.

Alternative Text Alternative Text

Eat a variety of foods to support gut health.


Alternative Text Alternative Text


Subscribe Policy

I understand and agree that the information I’ve provided will be used according to the terms of Abbott’s Privacy PolicyTerms and conditions apply.

Unless otherwise specified, all product and services names appearing in this Internet site are trademarks owned by or licensed to Abbott, its subsidiaries or affiliates. No use of any Abbott trademark, tradename, or trade dress in the site may be made without the prior written authorization of Abbott, except to identify the product or services of the company.